ea0081rc14.2 | Rapid Communications 14: Late Breaking | ECE2022
Gado Manuel
, Ghane Zahra
, Heinrich Annett
, Wiedersich Denise
, Bornstein Stefan R
, Rauner Martina
, Hofbauer Lorenz C
, Henneicke Holger
Glucocorticoids (GC) are one of the most potent anti-inflammatory pharmacological agents. However, owing to their pleiotropic nature, their clinical effectiveness is frequently limited by their deleterious off-target effects. Frequently, metabolic abnormalities arise from GC excess involving the development of dyslipidaemia, insulin resistance and muscle atrophy as well as excessive fat accumulation in both white adipose tissue (WAT) and the liver. In addition, suppressed ther...